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NCGC00229600
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NCGC00229600图片
CAS NO:1338824-20-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
NCGC00229600 是 TSHR 的变构反向激动剂。NCGC00229600 抑制 TSH 和刺激在 Graves 病中内源表达的 TSHRs 的抗体激活。
Cas No.1338824-20-6
分子式C30H29N3O3
分子量479.57
溶解度DMSO : 50 mg/mL (104.26 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NCGC00229600 is an allosteric inverse agonist of thyrotropin receptor (TSHR). NCGC00229600 inhibits both TSH and stimulating antibody activation of TSHRs endogenously expressed in Graves’ disease[1].

[1]. Neumann S, et al. A new small-molecule antagonist inhibits Graves’ disease antibody activation of the TSH receptor. J Clin Endocrinol Metab. 2011 Feb;96(2):548-54.