MRTX-EX185

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MRTX-EX185

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

产品介绍

MRTX-EX185 是负载 GDP 的 KRAS 和 KRAS(G12D) 的有效抑制剂，对 KRAS(G12D) 的 IC50 值为 90 nM。MRTX-EX185 还结合 GDP 负载的 HRAS。

分子式	C33H33FN6O2
分子量	564.65
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	MRTX-EX185 is a potent inhibitor of GDP-loaded KRAS and KRAS(G12D), with an IC50 of 90 nM for KRAS(G12D). MRTX-EX185 also binds GDP-loaded HRAS[1]. [1]. Vasta JD, et, al. KRAS is vulnerable to reversible switch-II pocket engagement in cells. Nat Chem Biol. 2022 Mar 21.