Ro60-0175 is a potent and selective agonist of 5-HT2C receptor. Ro60-0175 reduces cocaine self-administration, and the ability of cocaine to reinstate responding after extinction of drug-seeking behavior[1].

Ro60-0175 (1 mg/kg; s.c.) preserves the regularity of responding seen in control animals in drug-treated group, but drug-treated animals reach their break-points earlier[1].Ro60-0175 (0.5 mg/kg (SB242084); 1 mg/kg (Ro60-0175); s.c., i.p.) reduces responding for cocaine and effect is reversed by SB242084[1].Ro60-0175 (0.3, 1, and 3 mg/kg (Ro60-0175); 1 mg/kg (yohimbine); s.c.; i.p.) dose dependently attenuates the response increased by the yohimbine treatment alone relative to vehicle injection[1].Ro60-0175 (0.5 mg/kg (SB242084); 1 mg/kg (Ro60-0175); 1 mg/kg (yohimbine); s.c.; i.p.) reduces responding and that this effect is prevented by SB242084 pretreatment[1].Ro60-0175 (0.3, 1, and 3 mg/kg; s.c.) significantly reduces responding on the active lever in the reinstatement group[1].Ro60-0175 (0.5 mg/kg SB242084; 1 mg/kg Ro60-0175; s.c.; i.p.) reduces responding compared to vehicle in the reinstatement group, and that this effect is prevented by pretreatment with SB242084. For responding on the inactive lever, there are no significant main effects or interactions[1].

[1]. Fletcher PJ, et al. The 5-HT2C receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues. Neuropsychopharmacology. 2008;33(6):1402-1412.