| CAS NO: | 1703748-89-3 |
| 包装: | 5mg |
| 市场价: | 4140元 |
| Cas No. | 1703748-89-3 |
| 别名 | 福奈妥匹坦,Pronetupitant |
| 分子式 | C31H35F6N4O5P |
| 分子量 | 688.6 |
| 储存条件 | Store at -20°C, protect from light, stored under nitrogen |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Fosnetupitant (Pronetupitant) a methylene phosphate prodrug of Netupitant. Fosnetupitant (Pronetupitant) exhibits a pKi of 9.5 for human NK1 receptor[1]. Fosnetupitant (Pronetupitant) displays micromolar affinity for the 5-HT6 (pKi ∼ 5.2) receptor and type L Ca2+ channels (pKi ∼ 5.7) and does not bind all the other proteins investigated[1]. Pronetupitant is rapidly and extensively converted to Netupitant after i.v. injection in rats[1]. [1]. Ruzza C, et al. In vitro and in vivo pharmacological characterization of Pronetupitant, a prodrug of the neurokinin 1 receptor antagonist Netupitant. Peptides. 2015 Jul;69:26-32. |
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