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Hydralazine HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hydralazine HCl图片
CAS NO:304-20-1
包装与价格:
包装价格(元)
10mM (in 1mL Water)电议
100mg电议
500mg电议

产品介绍
Hydralazine HCl 是一种口服有效的抗高血压药,通过放松动脉血管中的平滑肌细胞层直接降低外周阻力。
Cas No.304-20-1
别名盐酸肼屈嗪
化学名phthalazin-1-ylhydrazine;hydrochloride
Canonical SMILESC1=CC=C2C(=C1)C=NN=C2NN.Cl
分子式C8H8N4.HCl
分子量196.64
溶解度≥ 35.3mg/mL in Water
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Hydralazine hydrochloride is a direct-acting vasodilator that is used as an antihypertensive agent.Target: OthersHydralazine hydrochloride (apresoline) is a direct-acting smooth muscle relaxant used to treat hypertension by acting as a vasodilator primarily in arteries and arterioles. By relaxing vascular smooth muscle, vasodilators act to decrease peripheral resistance, thereby lowering blood pressure and decreasing afterload. However, this only has a short term effect on blood pressure, as the system will reset to the previous, high blood pressure necessary to maintain pressure in the kidney necessary for natriuresis. The long term effect of antihypertensive drugs comes from their effects on the pressure natriuresis curve. It belongs to the hydrazinophthalazine class of drugs [1]. Hydralazine hydrochloride may reduce blood pressure when compared to placebo in patients with primary hypertension, however this data is based on before and after studies, not RCTs. Furthermore, its effect on clinical outcomes remains uncertain [2].

References:
[1]. Bourreli, B., et al., Additive effects of dihydralazine during enflurane or isoflurane hypotensive anaesthesia for spinal fusion. Can J Anaesth, 1988. 35(3 ( Pt 1)): p. 242-8.
[2]. Kandler, M.R., et al., Hydralazine for essential hypertension. Cochrane Database Syst Rev, 2010(8): p. CD004934.