| CAS NO: | 1022899-36-0 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
PCI-33380是布鲁顿酪氨酸激酶(BTK)的不可逆抑制剂(荧光探针)。
| Cas No. | 1022899-36-0 |
| Canonical SMILES | NC1=C(C(C2=CC=C(OC3=CC=CC=C3)C=C2)=NN4C(CCC5)CN5C(/C=C/CN6CCN(CCNC(CCC7=CC=C(C=C(C(C)=C8)[N]9=C8C)[N-]7[B+3]9([F-])[F-])=O)CC6)=O)C4=NC=N1 |
| 分子式 | C46H52BF2N11O3 |
| 分子量 | 855.78 |
| 溶解度 | DMSO : ≥ 50 mg/mL (58.43 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | PCI-33380 is an irreversible Bruton’s Tyrosine Kinase (BTK) inhibitor (fluorescent probe). [1]. Zuo Y, et al. A novel 2,5-diaminopyrimidine-based affinity probe for Bruton’s tyrosine kinase. Sci Rep. 2015 Nov 4;5:16136. [2]. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80. |
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