| CAS NO: | 1558021-37-6 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
TP0463518是一种有效的缺氧诱导因子脯氨酰羟化酶(PHDs)抑制剂，作用于人PHD2的Ki值为5.3nM。TP0463518还抑制人PHD1/PHD3，IC50分别为18和63nM，以及猴PHD2，IC50值为22nM。
| Cas No. | 1558021-37-6 |
| Canonical SMILES | ClC(C=C1)=CC=C1OC2=NC=C(CN3C(C(C(NCC(O)=O)=O)=C(O)CC3)=O)C=C2 |
| 分子式 | C20H18ClN3O6 |
| 分子量 | 431.83 |
| 溶解度 | DMSO : ≥ 125 mg/mL (289.47 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | TP0463518 is a potent hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor with a Ki value of 5.3 nM for human PHD2. TP0463518 also inhibits human PHD1/PHD3 with IC50s of 18 and 63 nM as well as monkey PHD2 with an IC50 value of 22 nM[1]. Reference: |
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