CAS NO: | 227963-15-7 |
包装 | 价格(元) |
250mg | 电议 |
500mg | 电议 |
Cas No. | 227963-15-7 |
别名 | L-000845704 |
Canonical SMILES | O=C1N([C@H](C2=CC=C(OC)N=C2)CC(O)=O)CCN1CCCC3=NC4=C(C=C3)CCCN4 |
分子式 | C23H29N5O4 |
分子量 | 439.51 |
溶解度 | DMSO : 250 mg/mL (568.82 mM) |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | MK-0429 is a potent integrin antagonist with IC50s of 12.2 nM (α5β1 integrin) and 2.8 nM (αvβ3 integrin), respectively. [1]. Zhou X, et al. An integrin antagonist (MK-0429) decreases proteinuria and renal fibrosis in the ZSF1 rat diabetic nephropathy model.Pharmacol Res Perspect. 2017 Oct; 5 (5). |