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PF-06250112
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF-06250112图片
CAS NO:1609465-89-5
包装:5mg
市场价:1710元

产品介绍
PF-06250112是一种有效的、高度选择性、口服有效的BTK抑制剂,IC50值为0.5nM,对BMX非受体酪氨酸激酶和TEC同样有抑制作用,IC50值分别为0.9nM和1.2nM。
Cas No.1609465-89-5
Canonical SMILESO=C(N)C1=C(N(N=C1C2=CC=C(C=C2)OC3=CC=C(C=C3F)F)[C@@H]4CN(CCC4)C#N)N
分子式C22H20F2N6O2
分子量438.43
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PF-06250112 is a potent, highly selective, orally bioavailable BTK inhibitor with an IC50 of 0.5 nM, shows inhibitory effect toward BMX nonreceptor tyrosine kinase and TEC with IC50s of 0.9 nM and 1.2 nM, respectively[1]. IC50: 0.5 nM (BTK), 0.9 nM (BMX), 1.2 nM (TEC)[1]

[1]. Rankin AL, et al. Selective inhibition of BTK prevents murine lupus and antibody-mediated glomerulonephritis. J Immunol. 2013 Nov 1;191(9):4540-50.