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(±)13(14)-EpDPA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(±)13(14)-EpDPA图片
CAS NO:895127-64-7
包装与价格:
包装价格(元)
25μg电议
50μg电议
100μg电议
500μg电议

产品介绍
(±)13(14)-EpDPA (13,14-EpDPE) 是细胞色素 P-450 环氧合酶与二十二碳六烯酸 (DHA) 反应的产物。
Cas No.895127-64-7
别名13,14-EpDPE
Canonical SMILESCC/C=C\C/C=C\C[C@@H]1[C@@H](O1)C/C=C\C/C=C\C/C=C\CCC(O)=O
分子式C22H32O3
分子量344.5
溶解度DMF: 25 mg/mL,DMSO: 20 mg/mL,Ethanol: 50 mg/mL,Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)13(14)-EpDPA is a docosahexaenoic acid epoxygenase metabolite, derived via epoxidation of the 13,14-double bond of DHA. It has been detected in rat brain and spinal cord and is a preferred substrate for soluble epoxide hydrolase with a Km value of 3.2 µM. (±)13(14)-EpDPA demonstrates antihyperalgesic activity in inflammatory and neuropathic pain models. (±)13(14)-EpDPA and other epoxy metabolites of DHA are also reported to potently inhibit angiogenesis and tumor growth in in vitro assays.