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Ganglioside GD1a mixture(sodium salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ganglioside GD1a mixture(sodium salt)图片
CAS NO:12707-58-3
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
Cas No.12707-58-3
别名双唾液酸神经节苷酯GD1A,Ganglioside B1
化学名ganglioside GD1a, disodium salt
Canonical SMILESO[C@H]1[C@@H](O[C@@H]([C@H](O)[C@@H]1O[C@]2(O[C@H]([C@@H]([C@H](C2)O)NC(C)=O)[C@@]([H])([C@]([H])(O)CO)O)C([O-])=O)CO)O[C@H]3[C@H]([C@H](O[C@H]([C@@H]3NC(C)=O)O[C@@H]4[C@@H]([C@H]([C@@H](O[C@@H]4CO)O[C@H]5[C@@H]([C@H]([C@@H](O[C@@H]5CO)OC[C@@]([H])([
分子式C84H146N4O39•2Na (for Sphingosine C18:1)
分子量1836.1
溶解度Soluble in water
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ganglioside GD1a is a sialic acid-containing glycosphingolipid found in brain, erythrocytes, bone marrow, testis, spleen, and liver. [1] It can be shed from the surface of tumor cells into the microenvironment where it influences tumor-host cell interactions to promote tumor cell proliferation, invasion, and metastasis. Ganglioside GD1a (20 μM) also increases endothelial cell proliferation. Furthermore, ganglioside GD1a has been shown to act as a functional coreceptor for toll-like receptor 2 (TLR2), enabling the recruitment of TLR2 to lipid rafts when bound by a bacterial toxin.[2] Ganglioside GD1a mixture contains ganglioside GD1a molecular species with C18:1 and C20:1 sphingoid backbones.

Reference:
[1]. Mukherjee, P., Faber, A.C., Shelton, L.M., et al. Thematic review series: Sphingolipids. Ganglioside GM3 suppresses the proangiogenic effects of vascular endothelial growth factor and ganglioside GD1a. J. Lipid Res. 49(5), 929-938 (2008).
[2]. Liang, S., Wang, M., Tapping, R.I., et al. Ganglioside GD1a is an essential coreceptor for Toll-like receptor 2 signaling in response to the B subunit of type IIb enterotoxin. J. Biol. Chem. 282(10), 7532-7542 (2007).