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MT-802
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
MT-802图片
CAS NO:2231744-29-7
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
MT-802 是基于PROTAC技术的、BTK 的降解剂，DC50 值为 1 nM。MT-802具有治疗C481S突变型慢性淋巴细胞白血病(CLL)的潜力。
Cas No.2231744-29-7
Canonical SMILESO=C(NC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1)COCCOCCN4CCC(N5N=C(C6=CC=C(OC7=CC=CC=C7)C=C6)C8=C(N)N=CN=C85)CC4
分子式C41H41N9O8
分子量787.82
溶解度DMSO: 100 mg/mL (126.93 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

MT-802 is a potent BTK degrader based on PROTAC technology, with a DC50 of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL)[1]. DC50: 1 nM (BTK)[1].

MT-802 degrades BTK with a DC50 of 9.1 nM with maximal degradation being observed by 250 nM[1].

[1]. Buhimschi AD, et al. Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation. Biochemistry. 2018 Jul 3;57(26):3564-3575.