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TM6089
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TM6089图片
CAS NO:863421-32-3
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
TM6089 是一种独特的 PHD 抑制剂,可刺激 HIF 活性而不会产生铁螯合作用,诱导血管生成并对缺血器官发挥保护作用。 TM6089 局部施用可增强血管生成,并且口服施用在表达缺氧反应的报告载体的转基因大鼠中刺激 HIF 活性。
Cas No.863421-32-3
Canonical SMILESO=C1N(C(C(C(CSC2=NC=CC=C2)=O)=C(N1C)N)=O)C
分子式C13H14N4O3S
分子量306.34
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

TM6089 is a unique Prolyl Hydroxylase (PHD) inhibitor which stimulates HIF activity without iron chelation and induces angiogenesis and exerts organ protection against ischemia. Local administration of TM6089 enhances angiogenesis, and oral administration stimulates HIF activity in transgenic rats expressing a hypoxia-responsive reporter vector[1].

[1]. Nangaku M, et al. A novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia. Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2548-54.