CAS NO: | 187960-08-3 |
包装 | 价格(元) |
500 μg | 电议 |
1mg | 电议 |
5mg | 电议 |
Cas No. | 187960-08-3 |
别名 | 金雀异黄酮-D4,NPI 031L-d4 |
Canonical SMILES | O=C1C(C2=C([2H])C([2H])=C(O)C([2H])=C2[2H])=COC3=CC(O)=CC(O)=C31 |
分子式 | C15H6D4O5 |
分子量 | 274.3 |
溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:6): 1 mg/ml |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Genistein-d4is intended for use as an internal standard for the quantification of genistein by GC- or LC-MS. Genistein is an isoflavonoid phytoestrogen that has been found in soybeans (G. max/S. hispida) and has kinase inhibitory, anticancer, pro-cancer, hepatoprotective, and antiviral properties.1It inhibits the tyrosine kinases EGFR, pp50v-Src, and pp110gag-fes(IC50= 6, 7-8, and 6.5 µg/ml, respectively) and decreases EGF-induced serine, threonine, and tyrosine phosphorylation of EGFR in A431 cells when used at a concentration of 20 µg/ml.2Genistein inhibits proliferation and induces apoptosis in a variety of cancer cells, including Bel 7402 hepatocellular carcinoma cells when used at a concentration of 10 µg/ml.1,3It reduces tumor invasion and angiogenesis in a Bel 7402 mouse subrenal capsule xenograft model when administered at a dose of 50 mg/kg per day.3However, when administered at the same dose on postnatal days 1-5, genistein increases the incidence of uterine adenocarcinoma in a mouse model of cancer induced by the estrogen receptor agonist diethylstilbestrol .4It reduces lipid accumulation and inflammation in the liver of ovariectomized (OVX) and non-OVX female rats in a model of high-fat high-fructose diet-induced nonalcoholic hepatosteatosis (NASH) when administered at a dose of 16 mg/kg per day.5Genistein (10 µM) also inhibits HIV-1 DNA synthesis in resting CD4+T cells.6 1.Spagnuolo, C., Russo, G.L., Orhan, I.E., et al.Genistein and cancer: Current status, challenges, and future directionsAdv. Nutr.6(4)408-419(2015) 2.Akiyama, T., Ishida, J., Nakagawa, S., et al.Genistein, a specific inhibitor of tyrosine-specific protein kinasesJ. Biol. Chem.262(1)5592-5595(1987) 3.Gu, Y., Zhu, C.-F., Iwamoto, H., et al.Genistein inhibits invasive potential of human hepatocellular carcinoma by altering cell cycle, apoptosis, and angiogenesisWorld J. Gastroenterol.11(41)6512-6517(2005) 4.Newbold, R.R., Banks, E.P., Bullock, B., et al.Uterine adenocarcinoma in mice treated neonatally with genisteinCancer Res.614325-4328(2001) 5.Pummoung, S., Werawatganon, D., Klaikeaw, N., et al.Genistein-attenuated hepatic steatosis and inflammation in nonalcoholic steatohepatitis with bilateral ovariectomized ratsPharmacogn. Mag.14(55)20-24(2018) 6.Guo, J., Xu, X., Rasheed, T.K., et al.Genistein interferes with SDF-1- and HIV-mediated actin dynamics and inhibits HIV infection of resting CD4 T cellsRetrovirology1062(2013) |