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IMS 2186
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
IMS 2186图片
CAS NO:1031206-36-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
An anti-choroidal neovascularization agent
Cas No.1031206-36-6
Canonical SMILESCC1=CC=C(OC/C(C2=O)=C\C3=CC=C(OC)C(O)=C3)C2=C1
分子式C18H16O4
分子量296.3
溶解度DMSO: 5 mg/ml,Ethanol: 1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IMS 2186 is an anti-choroidal neovascularization agent.1It inhibits proliferation of NIH3T3 mouse and IMR-90 human fibroblasts (IC50s = 0.5-3 µM), as well as in a panel of eight human cancer cell lines, including ovarian, lung, colon, and pancreatic cancer cells (IC50s = 0.3-3 µM). IMS 2186 (10 µM) decreases migration of THP-1 macrophages in wound healing and chamber assays. Subcutaneous administration of IMS 2186 (20 µg/animal) inhibits VEGF-induced blood vessel formation in a MatrigelTMplug assay in mice. It reduces ocular leakage, as well as cellular proliferation and infiltration in a rat model of laser-induced choroidal neovascularization when administered intravitreally at a dose of 100 µg/eye.

1.Falkenstein, I.A., Cheng, L., Wong-Staal, F., et al.Toxicity and intraocular properties of a novel long-acting anti-proliferative and anti-angiogenic compound IMS2186Curr. Eye Res.33(7)599-609(2008)