生物活性
Purvalanol A是一种有效的细胞渗透性细胞周期蛋白依赖性蛋白激酶（cdk）抑制剂。对于cdc2/cyclin B，cdk2/cyclin A，cdk2/cyclin E，cdk4/cyclin D1和cdk5-p35，IC50值分别为4、70、35、850和75 nM。
靶点信息
| Cdc2/CyclinB | CDK2/CyclinE | CDK2/CyclinA | CDK4/CyclinD1 | |
| 4 nM | 35 nM | 70 nM | 850 nM | |
化学数据
| 目录号 | A15517 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 388.89 |
| Formula | C19H25ClN6O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 212844-53-6 |
| Synonyms | NG-60 |
| SMILES | CC(C)N1C2=NC(N[C@H](C(C)C)CO)=NC(NC3=CC(Cl)=CC=C3)=C2N=C1 |
溶解度
| In vitro | DMSO | Warmed: 53 mg/mL (136.28 mM) |
| Water | Insoluble |
| Ethanol | Warmed: 11 mg/mL (28.28 mM) |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 25.71 mL | 128.57 mL | 257.14 mL |
| 0.5 mM | 5.14 mL | 25.71 mL | 51.43 mL |
| 1 mM | 2.57 mL | 12.86 mL | 25.71 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.14 mL |
*The above data is based on the productmolecular weight 388.89. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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