PD 180970 是一种高效的 ATP 竞争性 p210Bcr-Abl 激酶抑制剂，抑制 p210Bcr-Abl 的自磷酸化的 IC50 为 5 nM。
| Cas No. | 287204-45-9 |
| 化学名 | 6-(2,6-dichlorophenyl)-2-(4-fluoro-3-methylanilino)-8-methylpyrido[2,3-d]pyrimidin-7-one |
| Canonical SMILES | CC1=C(C=CC(=C1)NC2=NC=C3C=C(C(=O)N(C3=N2)C)C4=C(C=CC=C4Cl)Cl)F |
| 分子式 | C21H15Cl2FN4O |
| 分子量 | 429.27 |
| 溶解度 | <21.46mg/ml in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | ATP-competitive inhibitor of p210bcr/abl tyrosine kinase; selectively induces apoptosis in chronic myeloid leukemia (CML) K562 cells. Inhibits in vivo tyrosine phosphorylation of Gab2, CrkL and p210bcr/abl (IC50 values are 80, 80 and 170 nM respectively). |
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