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(-)-epigallocatechin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(-)-epigallocatechin图片
CAS NO:970-74-1
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
(-)-表没食子儿茶素 (Epigallocatechin) 是绿茶中含量最丰富的类黄酮，可与未折叠的天然多肽结合，阻止转化为淀粉样蛋白原纤维。
Cas No.970-74-1
别名(-)-表没食子儿茶素; Epigallocatechin; L-Epigallocatechin
化学名(2R,3R)-2-(3,4,5-trihydroxyphenyl)chroman-3,5,7-triol
Canonical SMILESO[C@@H]1CC2=C(C=C(O)C=C2O)O[C@@H]1C3=CC(O)=C(O)C(O)=C3
分子式C15H14O7
分子量306.27
溶解度DMF: 25 mg/ml,DMSO: 15 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 1 mg/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(-)-epigallocatechin is a polyphenol in green tea [1].

(-)-epigallocatechin (EGC) plays an important role in cell growth inhibition, apoptosis and bone metabolism.

(-)-epigallocatechin is a polyphenol in green tea. In MCF-7 and MDA-MB-231 breast cancer cell lines, EGC significantly inhibited cell growth and induced apoptosis, which were independent of p53 and required Fas signaling [1]. In H1299 cells, EGC (10-40 μM) reduced cell viability in a dose dependent way. In Hep-3B cells, EGC (40/80 μM) also reduced cell viability. However, EGC (20 μM) slightly increased cell viabilities in SK-Hep-1 and OECM-1 cells but significantly decreased cell viabilities at concentrations up to 40 μM. EGC exhibited cytotoxicity with IC50 values of 26, 33 and 22 μM in H1299, OECM-1 and SAS cells, respectively. In H1299, OECM-1 and SAS cells, EGC (40 μM) induced apoptosis by 30, 28 and 24%, respectively. In H1299 cells, EGC (40 μM) inhibited hTERT promoter activity in a time- and dose- dependent way and also inhibited hTERT mRNA expression, which was important for cell proliferation [2].

In ICR mice, EGC (0.5 and 1.0 g/kg/d) significantly inhibited platelet aggregation by 18.4% and 25.6% respectively and also significantly prolonged blood clotting time (BCT) and bleeding time (BT), which suggested that the blood anticoagulation and antiplatelet activity of EGC [3].

References:
[1].  Vergote D, Cren-Olivé C, Chopin V, et al. (-)-Epigallocatechin (EGC) of green tea induces apoptosis of human breast cancer cells but not of their normal counterparts. Breast Cancer Res Treat, 2002, 76(3): 195-201.
[2].  Lin SC, Li WC, Shih JW, et al. The tea polyphenols EGCG and EGC repress mRNA expression of human telomerase reverse transcriptase (hTERT) in carcinoma cells. Cancer Lett, 2006, 236(1): 80-88.
[3].  Chen XQ, Wang XB, Guan RF, et al. Blood anticoagulation and antiplatelet activity of green tea (-)-epigallocatechin (EGC) in mice. Food Funct, 2013, 4(10): 1521-1525.