Cercosporin

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Cercosporin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

35082-49-6

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议

产品介绍

尾孢菌素由植物病原体 Cercosporakikuchii 和 elsinochromes 产生，后者是 elsinoe 真菌家族的色素。 Cercosporin 是一种有效的光敏剂，具有短的活化波长，主要适用于表面光动力疗法 (PDT) 治疗，尤其是在需要避免穿孔时。Cercosporin 含有 PKC 活性所需的苝醌结构特征，IC50 为 0.6-1.3 μM。

Cas No.	35082-49-6
别名	尾孢菌素
化学名	(13bR)-6,12-dihydroxy-8,9-bis[(2R)-2-hydroxypropyl]-7,10-dimethoxy-perylo[1,12-def]-1,3-dioxepin-5,11-dione
Canonical SMILES	COC(C1=O)=C(CC(O)C)C2=C3C(C(C(C=C4OCO5)=O)=C(O)C(OC)=C3CC(C)O)=C4C6=C5C=C(O)C1=C26
分子式	C₂₉H₂₆O₁₀
分子量	534.5
溶解度	DMF: soluble,DMSO: soluble,Ethanol: soluble
储存条件	Store at -20°C,protect from light
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Cercosporin is produced by a plant pathogen, Cercosporakikuchii, and the elsinochromes, pigments of the elsinoe family of fungi. Cercosporin is a potent photosensitizer with a short activation wavelength, mostly suitable for superficial photodynamic therapy (PDT) treatments, especially when it is necessary to avoid perforations[1].Cercosporin contains the perylenequinone structural features necessary to PKC activity with an IC50 of 0.6-1.3 μM[2]. Cercosporin (0.8-8.0 μM; 30 s, 60 s, 90 s, 120 s) photodynamic therapy (PDT) effect is stronger in T98G cells than in U87 or MCF7 cells, the LD50 value for the T98G cells (0.14 J cm2) is much less than the LD50 value for MCF-7 and U87 cell lines (0.26 and 0.24 J cm2, respectively)[1].Cercosporin (0-3 μΜ; 24 hours) interplays with copper results in a synergistic cytotoxicity in MCF7 and T98G cells, that is, S(CuSO4 + Cerco) << S(CuSO4) x S(Cerco), barely has an additive effect in U87 cells[1]. References: [1]. Mastrangelopoulou M, et al. Cytotoxic and Photocytotoxic Effects of Cercosporin on Human Tumor Cell Lines. Photochem Photobiol. 2019 Jan;95(1):387-396. [2]. Morgan BJ, et al. Design, synthesis, and investigation of protein kinase C inhibitors: total syntheses of (+)-calphostin D, (+)-phleichrome, cercosporin, and new photoactive perylenequinones. J Am Chem Soc. 2009 Jul 8;131(26):9413-25.