L-erythro Sphingosine is a synthetic stereoisomer of sphingosine (d18:1).
Cas No. | 6036-75-5 |
别名 | 双琥珀酰亚胺辛二酸酯 |
Canonical SMILES | OC[C@@H](N)[C@@H](O)/C=C/CCCCCCCCCCCCC |
分子式 | C18H37NO2 |
分子量 | 299.5 |
溶解度 | Chloroform: soluble,DMSO: soluble,Ethanol: soluble |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | L-erythro Sphingosine is a synthetic stereoisomer of sphingosine (d18:1) . It inhibits protein kinase C (PKC) in vitro (IC50 = 3.3 mol%) and superoxide generation induced by phorbol 12-myristate 13-acetate in neutrophils as well as reduces growth of CHO cells (IC50s = 1.3 and 2 μM, respectively). L-erythro Sphingosine also inhibits dephosphorylation of the tumor suppressor retinoblastoma gene product (pRb; EC50 = 5 μM) and growth of MOLT-4 acute lymphoblastic leukemia cells (IC50 = 3.7 μM). |