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SMAD3 Inhibitor,SIS3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SMAD3 Inhibitor,SIS3图片
CAS NO:1009104-85-1
包装与价格:
包装价格(元)
500μg电议
1mg电议
5mg电议

产品介绍
SMAD3 Inhibitor, SIS3 是一种有效的选择性 Smad3 磷酸化抑制剂。
Cas No.1009104-85-1
化学名1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-propen-1-one
Canonical SMILESCOC1=CC(CCN(C(/C=C/C2=C(C3=CC=CC=C3)N(C)C4=C2C=CC=N4)=O)C5)=C5C=C1OC
分子式C28H27N3O3
分子量453.5
溶解度30mg/mL in ethanol, or in DMSO, or in DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SMAD3 is a receptor-regulated intracellular protein that functions downstream of TGF-β and activin receptors and mediates their signaling, playing a role in cell proliferation, differentiation, apoptosis and formation of extracellular matrix. SMAD3 Inhibitor, SIS3 selectively inhibits TGF-β and activin signaling by suppressing Smad3 phosphorylation (IC50 = 3 &#181M) without affecting the MAPK/p38, ERK, or PI3-kinase signaling pathways.[1] It has been shown to reduce TGF-β1-induced type 1 procollagen expression and myofibroblast differentiation in normal dermal fibroblasts as well as scleroderma fibroblasts.[1]

Reference:
[1]. Jinnin, M., Ihn, H., and Tamaki, K. Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-β1-induced extracellular matrix expression. Molecular Pharmacology 69(2), 597-607 (2006).