AST2818 mesylate

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AST2818 mesylate

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2130958-55-1

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议

产品介绍

Alflutinib (Furmonertinib) mesylate 是一种有效的 EGFR 抑制剂。 Alflutinib (Furmonertinib) mesylate 抑制 EGFR 活性突变以及 T790M 获得性耐药突变。阿氟替尼（Furmonertinib）甲磺酸盐具有研究癌症疾病，尤其是非小细胞肺癌（NSCLC）的潜力。

Cas No.	2130958-55-1
别名	甲磺酸伏美替尼; Furmonertinib mesylate; AST2818 mesylate
Canonical SMILES	C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OCC(F)(F)F)N=C1N(CCN(C)C)C)=O.CS(=O)(O)=O
分子式	C₂₉H₃₅F₃N₈O₅S
分子量	664.7
溶解度	DMSO : 5 mg/mL (7.52 mM)
储存条件	Store at -20°C,unstable in solution, ready to use.
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	AST2818 mesylate is an EGFR inhibitor. AST2818 mesylate is designed to inhibit EGFR active mutations as well as the T790M acquired resistant mutation[1]. [1]. Y.Shi, et al. P2.03-028 Third Generation EGFR Inhibitor AST2818 (Alflutinib) in NSCLC Patients with EGFR T790M Mutation: A phase1/2 Multi-Center Clinical Trial. J Thorac Oncol. 2017 Nov, 12(11): S2138.