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Balsalazide sodium hydrate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Balsalazide sodium hydrate图片
CAS NO:150399-21-6
包装与价格：
包装价格(元)
250mg电议
500mg电议

产品介绍
Balsalazide sodium hydrate 可通过调节 IL-6/STAT3 通路来发挥相关的抑癌作用。
Cas No.150399-21-6
别名巴柳氮钠水合物; Balsalazide disodium dihydrate
Canonical SMILES[O-]C(CCNC(C1=CC=C(/N=N/C2=CC=C([O-])C(C(O)=O)=C2)C=C1)=O)=O.[Na+].[Na+].O.O
分子式C17H17N3Na2O8
分子量437.31
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Balsalazide sodium hydrate could suppress colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway. STAT3 IL-6

At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group[1]. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug[2].

[1]. Do EJ, et al. Suppression of colitis-associated carcinogenesis through modulation of IL-6/STAT3 pathway by balsalazide and VSL#3. J Gastroenterol Hepatol. 2016 Aug;31(8):1453-61. [2]. Kruis W, et al. Low dose balsalazide (1.5 g twice daily) and mesalazine (0.5 g three times daily) maintained remission of ulcerative colitis but high dose balsalazide (3.0 g twice daily) was superior in preventing relapses. Gut, 2001. 49(6): p. 783-789.