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Itacitinib adipate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Itacitinib adipate图片
CAS NO:1334302-63-4
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
Itacitinib adipate 是一个选择性 JAK1 抑制剂,已经在骨髓纤维化的 II 期试验中测试其疗效和安全性。
Cas No.1334302-63-4
Canonical SMILESN#CCC1(N2N=CC(C3=C4C(NC=C4)=NC=N3)=C2)CN(C5CCN(C(C6=C(F)C(C(F)(F)F)=NC=C6)=O)CC5)C1.O=C(O)CCCCC(O)=O
分子式C32H33F4N9O5
分子量699.66
溶解度DMSO: ≥ 137.5 mg/mL (196.52 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Itacitinib adipate is an orally bioavailable and selective JAK1 inhibitor which has been tested for efficacy and safety in a phase II trial in myelofibrosis. JAK1

[1]. Griesshammer M, et al. The BCR-ABL1-negative myeloproliferative neoplasms: a review of JAK inhibitors in the therapeutic armamentarium. Expert Opin Pharmacother. 2017 Dec;18(18):1929-1938.