CAS NO: | 65182-56-1 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
Cas No. | 65182-56-1 |
别名 | 3-氨基-2-氯-6-三氟甲基吡啶 |
Canonical SMILES | OC1=CC=CC=C1C2=NC(N=CC=C3)=C3C=C2 |
分子式 | C14H10N2O |
分子量 | 222.2 |
溶解度 | DMF: 10 mg/ml,DMF:PBS (pH 7.2) (1:1): 0.50 mg/ml |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | 2-(1,8-Naphthyridin-2-yl)phenol (2-NP) is an enhancer of STAT1 activity.1 It enhances IFN-γ-induced STAT1-dependent signaling, but not IFN-γ-induced STAT3-dependent signaling or TNF-α-induced NF-κB-dependent signaling in cell-based reporter assays when used at a concentration of 45 μM. 2-NP (45 μM) increases IFN-γ-induced expression of the STAT1 target gene IRF3 and STAT1 phosphorylation in NIH3T3 cells. It increases growth inhibition of MCF-7 and 2fTGH cancer cells induced by IFN-γ at the same concentration. 1.Lynch, R.A., Etchin, J., Battle, T.E., et al.A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-γ in human cancer cellsCancer Res.67(3)1254-1261(2007) |