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2-(1,8-naphthyridin-2-yl)phenol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
2-(1,8-naphthyridin-2-yl)phenol图片
CAS NO:65182-56-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
2-(1,8-Naphthyridin-2-yl)phenol 是 STAT1 转录的选择性增强剂。 2-(1,8-Naphthyridin-2-yl)phenol 可增强 IFN-γ 的能力;抑制人乳腺癌和纤维肉瘤细胞的增殖。
Cas No.65182-56-1
别名3-氨基-2-氯-6-三氟甲基吡啶
Canonical SMILESOC1=CC=CC=C1C2=NC(N=CC=C3)=C3C=C2
分子式C14H10N2O
分子量222.2
溶解度DMF: 10 mg/ml,DMF:PBS (pH 7.2) (1:1): 0.50 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

2-(1,8-Naphthyridin-2-yl)phenol (2-NP) is an enhancer of STAT1 activity.1 It enhances IFN-γ-induced STAT1-dependent signaling, but not IFN-γ-induced STAT3-dependent signaling or TNF-α-induced NF-κB-dependent signaling in cell-based reporter assays when used at a concentration of 45 μM. 2-NP (45 μM) increases IFN-γ-induced expression of the STAT1 target gene IRF3 and STAT1 phosphorylation in NIH3T3 cells. It increases growth inhibition of MCF-7 and 2fTGH cancer cells induced by IFN-γ at the same concentration.

1.Lynch, R.A., Etchin, J., Battle, T.E., et al.A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-γ in human cancer cellsCancer Res.67(3)1254-1261(2007)