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C6 Urea Ceramide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
C6 Urea Ceramide图片
CAS NO:486991-52-0
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
An inhibitor of neutral ceramidase
Cas No.486991-52-0
Canonical SMILESCCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC(NCCCCCC)=O)CO
分子式C25H50N2O3
分子量426.7
溶解度DMF: 0.5mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

C6 urea ceramide is an inhibitor of neutral ceramidase.1 It increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and in HT-29 colon cancer cells but not in MEFs lacking neutral ceramidase. It inhibits proliferation of, and induces apoptosis and autophagy in HT-29, but not non-cancerous RIE-1, cells when used at concentrations of 5 and 10 μM. C6 urea ceramide decreases total β-catenin, increases phosphorylated β-catenin, and induces colocalization of β-catenin with the 20S proteasome in HT-29 and HCT116, but not RIE-1, cells. It reduces tumor growth and increases C16, C18, C20, and C24 ceramide levels in tumor tissue in an HT-29 mouse xenograft model when administered at doses of 1.25, 2.5, and 5 mg/kg for five days.

|1. GarcÍa-Barros, M., Coant, N., Kawamori, T., et al. Role of neutral ceramidase in colon cancer. FASEB J. 30(12), 4159-4171 (2016).