LC3-mHTT-IN-AN1

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LC3-mHTT-IN-AN1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

486443-73-6

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品介绍

LC3-mHTT-IN-AN1 (Compound AN1) 是一种 mHTT-LC3 连接化合物，LC3-mHTT-IN-AN1 与突变型亨廷顿蛋白 (mHTT) 和 LC3B 相互作用，但不与 wtHTT 或无关的对照蛋白相互作用。LC3-mHTT-IN-AN1 以等位基因选择性的方式降低了亨廷顿病 (HD) 小鼠神经元中mHTT水平。

Cas No.	486443-73-6
Canonical SMILES	BrC1=CC=C(C/2=C1)NC(C2=C/C3=CC(Br)=C(C(O)=C3)O)=O
分子式	C₁₅H₉Br₂NO₃
分子量	411.04
溶解度	DMSO: 125 mg/mL (304.11 mM); Water:< 0.1 mg/mL (insoluble)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	LC3-mHTT-IN-AN1 (Compound AN1) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN1 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons[1]. [1]. Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Nov;575(7781):203-209.