| CAS NO: | 1189971-72-9 |
| 包装: | 1mg |
| 市场价: | 3402元 |
| Cas No. | 1189971-72-9 |
| Canonical SMILES | CCNC([2H])([2H])C([2H])([2H])CC(C)NC1=CC=NC2=C1C=CC(Cl)=C2 |
| 分子式 | C16H18ClD4N3 |
| 分子量 | 295.8 |
| 溶解度 | DMSO: slightly soluble,Methanol: slightly soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Desethylchloroquine-d4is intended for use as an internal standard for the quantification of desethylchloroquine by GC- or LC-MS. Desethylchloroquine is a major active metabolite of chloroquine .1Desethylchloroquine is formed when chloroquine undergoes dealkylation, primarily by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 and to a lesser extent by CYP2D6. It inhibits the growth of theP. falciparumstrain LA136in vitro(IC50= 9.9 ng/ml).2 1.Projean, D., Baune, B., Farinotti, R., et al.In vitro metabolism of chloroquine: Identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formationDrug Metab. Dispos.31(6)748-754(2003) 2.Aderounmu, F.A.In vitro assessment of the antimalarial activity of chloroquine and its major metabolitesAnn. Trop. Med. Parasitol.78(6)581-585(1984) |
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