| CAS NO: | 85047-14-9 |
| 包装 | 价格(元) |
| 500 μg | 电议 |
| 1mg | 电议 |
| Cas No. | 85047-14-9 |
| Canonical SMILES | [2H]C(C([2H])([2H])O1)([2H])N=C1NC(C2CC2)C3CC3 |
| 分子式 | C10H12D4N2O |
| 分子量 | 184.3 |
| 溶解度 | DMF: Soluble,DMSO: Soluble,Methanol: Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Rilmenidine-d4is intended for use as an internal standard for the quantification of rilmenidine by GC- or LC-MS. Rilmenidine is an antihypertensive agent.1It binds to imidazole receptors in bovine rostral ventrolateral medulla homogenates (Ki= 6.1 nM), as well as α2-adrenergic receptors in bovine prefrontal cortex homogenates (Ki= 87 nM). Rilmenidine induces hypotension and bradycardia in anesthetized rats (ED50s = 0.25 and 0.35 mg/kg, respectively). It also reduces mean arterial pressure and renal sympathetic nerve activity in a rabbit model of renal hypertension induced by a renal artery clip when administered at a dose of 2.5 mg/kg.2Rilmenidine (1 µM) increases levels of LC3-II, a marker of autophagy, in PC12 cells.3Formulations containing rilmenidine have been used in the treatment of hypertension. 1.Gomez, R.E., Ernsbarger, P., Feinland, G., et al.Rilmenidine lowers arterial pressure via imidazole receptors in brainstem C1 areaEur. J. Pharmacol.195(2)181-191(1991) 2.Burke, S.L., Evans, R.G., and Head, G.A.Effects of chronic sympatho-inhibition on renal excretory function in renovascular hypertensionJ. Hypertens.29(5)945-952(2011) 3.Williams, A., Sarkar, S., Cuddon, P., et al.Novel targets for Huntington's disease in an mTOR-independent autophagy pathwayNat. Chem. Biol.4(5)295-305(2008) |
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