您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > PSI(trifluoroacetate salt)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
PSI(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PSI(trifluoroacetate salt)图片
包装:1mg
市场价:1194元

产品介绍
A proteasome inhibitor
Canonical SMILESO=C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCC(OC(C)(C)C)=O)C(N[C@@H](C)C(N[C@H](C=O)CC(C)C)=O)=O)=O)OCC1=CC=CC=C1.OC(C(F)(F)F)=O
分子式C32H50N4O8•XCF3COOH
分子量618.8
溶解度Formic Acid: 1 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PSI is a synthetic peptide proteasome inhibitor.1,2,3It inhibits the acidic and neutral chymotrypsin-like activities of the 20S proteasome (IC50s = 0.25 and 6.5 µM, respectively).3PSI is cytotoxic to HL-60, KG-1a, RWLeu-4, AR230, and K562 human leukemia cells (IC50s = 4.9, 17.5, 7.8, 7.3, and 10 nM, respectively).4It selectively induces apoptosis in subconfluent bovine aortic endothelial cells (BAECs) and human umbilical vein endothelial cells (HUVECs; EC50s = 24 and 7 nM, respectively) over confluent BAECs and HUVECs (EC50s = 8,150 and 7,830 nM, respectively).5PSI induces accumulation of ubiquitin-protein conjugates in HT4 mouse neuronal cells.6

1.Collins, G.A., and Goldberg, A.L.The logic of the 26S proteasomeCell169(5)792-806(2017) 2.Orlowski, M., and Wilk, S.Catalytic activities of the 20 S proteasome, a multicatalytic proteinase complexArch. Biochem. Biophys.383(1)1-16(2000) 3.Figueiredo-Pereira, M.E., Chen, W.-E., Yuan, H.-M., et al.A novel chymotrypsin-like component of the multicatalytic proteinase complex optimally active at acidic pHArch. Biochem. Biophys.317(1)69-78(1995) 4.Soligo, D., Servida, F., Delia, D., et al.The apoptogenic response of human myeloid leukaemia cell lines and of normal and malignant haematopoietic progenitor cells to the proteasome inhibitor PSIBr. J. Haematol.113(1)126-135(2001) 5.Drexler, H.C., Risau, W., and Konerding, M.A.Inhibition of proteasome function induces programmed cell death in proliferating endothelial cellsFASEB J.14(1)65-77(2000) 6.Figueiredo-Pereira, M.E., Berg, K.A., and Wilk, S.A new inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (20S proteasome) induces accumulation of ubiquitin-protein conjugates in a neuronal cellJ. Neurochem.63(4)1578-1581(1994)