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Monascuspiloin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Monascuspiloin图片
CAS NO:1011244-19-1
包装与价格:
包装价格(元)
100µg电议
500µg电议

产品介绍
A fungal metabolite with anticancer activity
Cas No.1011244-19-1
Canonical SMILESC[C@]12[C@@](CC3=C(COC(/C=C/C)=C3)C2=O)([H])[C@@H]([C@H](O)CCCCC)C(O1)=O
分子式C21H28O5
分子量360.4
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Monascuspiloin is a fungal metabolite that has been found inM. pilosusM93-fermented rice.1It induces endoplasmic reticulum stress and autophagy in PC3 prostate cancer cells. Monascuspiloin (15-45 µM) decreases viability of PC3 cells and has an additive effect on the reduction in viability of PC3 cells induced by irradiation when used at a concentration of 25 µM. It induces intratumor apoptosis and autophagy and reduces tumor growth in a PC3 mouse xenograft model when administered at doses of 40 and 120 mg/kg.2

1.Chiu, H.-W., Fang, W.-H., Chen, Y.-L., et al.Monascuspiloin enhances the radiation sensitivity of human prostate cancer cells by stimulating endoplasmic reticulum stress and inducing autophagyPLoS One7(7)e40462(2012) 2.Chen, R.-J., Hung, C.-M., Chen, Y.-L., et al.Monascuspiloin induces apoptosis and autophagic cell death in human prostate cancer cells via the Akt and AMPK signaling pathwaysJ. Agric. Food Chem.60(29)7185-7193(2012)