| CAS NO: | 1217449-45-0 |
| 包装: | 1.2 ml |
| 市场价: | 14742元 |
| Cas No. | 1217449-45-0 |
| 别名 | 黄曲霉毒素B1-(全碳-13) |
| Canonical SMILES | O=[13C]1[13C]2=[13C]([13CH2][13CH2][13C]2=O)[13C]3=[13C]([13C]([13C@@]([13CH]=[13CH]O4)([H])[13C@@]4([H])O5)=[13C]5[13CH]=[13C]3O[13CH3])O1 |
| 分子式 | [13C]17H12O6 |
| 分子量 | 329.1 |
| 溶解度 | Acetonitrile: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Aflatoxin B1-13C17(AFB1-13C17) is intended for use as an internal standard for the quantification of AFB1by GC- or LC-MS. AFB1is a genotoxic mycotoxin that has been found inAspergillus.1,2It induces the formation of DNA adducts in rat liver microsomes.1AFB1induces transversion of guanine to thymine at codon 29 of the p53 tumor suppressor gene, a mutation commonly seen in hepatocellular carcinoma patients living in regions with high levels of aflatoxin contamination, in HepG2 cells.2In vivo, AFB1(50 and 100 µg/kg) induces hepatocellular carcinoma tumor formation in rats.3 1.Essigmann, J.M., Croy, R.G., Nadzan, A.M., et al.Structural identification of the major DNA adduct formed by aflatoxin B1 in vitroProc. Natl. Acad. Sci. USA74(5)1870-1874(1977) 2.Aguilar, F., Hussain, S.P., and Cerutti, P.Aflatoxin B1 induces the transversion of G ->T in codon 249 of the p53 tumor suppressor gene in human hepatocytesProc. Natl. Acad. Sci. USA90(18)8586-8590(1993) 3.Wogan, G.N., Paglialunga, S., and Newberne, P.M.Carcinogenic effects of low dietary levels of aflatoxin B1 in ratsFd. Cosmet. Toxicol.12(5-6)681-685(1974) |
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