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Aflatoxin B1-13C17
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Aflatoxin B1-13C17图片
CAS NO:1217449-45-0
包装:1.2 ml
市场价:14742元

产品介绍
An internal standard for the quantification of aflatoxin B1
Cas No.1217449-45-0
别名黄曲霉毒素B1-(全碳-13)
Canonical SMILESO=[13C]1[13C]2=[13C]([13CH2][13CH2][13C]2=O)[13C]3=[13C]([13C]([13C@@]([13CH]=[13CH]O4)([H])[13C@@]4([H])O5)=[13C]5[13CH]=[13C]3O[13CH3])O1
分子式[13C]17H12O6
分子量329.1
溶解度Acetonitrile: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Aflatoxin B1-13C17(AFB1-13C17) is intended for use as an internal standard for the quantification of AFB1by GC- or LC-MS. AFB1is a genotoxic mycotoxin that has been found inAspergillus.1,2It induces the formation of DNA adducts in rat liver microsomes.1AFB1induces transversion of guanine to thymine at codon 29 of the p53 tumor suppressor gene, a mutation commonly seen in hepatocellular carcinoma patients living in regions with high levels of aflatoxin contamination, in HepG2 cells.2In vivo, AFB1(50 and 100 µg/kg) induces hepatocellular carcinoma tumor formation in rats.3

1.Essigmann, J.M., Croy, R.G., Nadzan, A.M., et al.Structural identification of the major DNA adduct formed by aflatoxin B1 in vitroProc. Natl. Acad. Sci. USA74(5)1870-1874(1977) 2.Aguilar, F., Hussain, S.P., and Cerutti, P.Aflatoxin B1 induces the transversion of G ->T in codon 249 of the p53 tumor suppressor gene in human hepatocytesProc. Natl. Acad. Sci. USA90(18)8586-8590(1993) 3.Wogan, G.N., Paglialunga, S., and Newberne, P.M.Carcinogenic effects of low dietary levels of aflatoxin B1 in ratsFd. Cosmet. Toxicol.12(5-6)681-685(1974)