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Aranciamycin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Aranciamycin图片
CAS NO:72389-06-1
包装:1mg
市场价:2858元

产品介绍
A fungal metabolite with diverse biological activities
Cas No.72389-06-1
别名阿雷西霉素
Canonical SMILESO=C1C2=CC3=C([C@@H](O[C@H]4[C@H](OC)[C@H](O)[C@@H](O)[C@H](C)O4)[C@H](OC)[C@](C)(O)C3=O)C(O)=C2C(C5=C(O)C=CC=C51)=O
分子式C27H28O12
分子量544.5
溶解度Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Aranciamycin is a fungal metabolite that has been found inStreptomycesand has diverse biological activities.1,2It inhibitsC. histolyticumcollagenase but not elastase or trypsin in cell-free assays (IC50s = 0.37, >10, and >10 µM, respectively).1Aranciamycin is active againstM. bovisandB. subtilis(MICs = 30 and 15 µM, respectively).2It is cytotoxic to HepG2 cells (IC50= 18 µM).

1.Bols, M., Biderup, L., Hansen, J., et al.Inhibition of collagenase by aranciamycin and aranciamycin derivativesJ. Med. Chem.35(15)1768-2771(1992) 2.Khalil, Z.G., Raju, R., Piggott, A.M., et al.Aranciamycins I and J, antimycobacterial anthracyclines from an Australian marine-derived Streptomyces spJ. Nat. Prod.78(4)949-952(2015)