| CAS NO: | 1133695-49-4 |
| 包装 | 价格(元) |
| 500 μg | 电议 |
| 1mg | 电议 |
| Cas No. | 1133695-49-4 |
| 别名 | 1-[[4-[2-(六氢-1H-氮杂卓-1-基)乙氧基-1,1,2,2-D4]苯基]甲基]-2-(4-羟基苯基)-3-甲基-1H-吲哚-5-醇,TSE-424-d4 |
| Canonical SMILES | CC1=C(C2=CC=C(O)C=C2)N(CC3=CC=C(OC([2H])([2H])C([2H])([2H])N4CCCCCC4)C=C3)C5=C1C=C(O)C=C5 |
| 分子式 | C30H30D4N2O3 |
| 分子量 | 474.6 |
| 储存条件 | Store at 2°C to 8°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Bazedoxifene-d4is intended for use as an internal standard for the quantification of bazedoxifene by GC- or LC-MS. Bazedoxifene is a third generation selective estrogen receptor modulator (SERM). It is an indole-based ER ligand that binds to both ERα (IC50= 26 nM) and ERβ (IC50= 99 nM).1Bazedoxifene antagonizes 17β-estradiol-dependent MCF-7 and T47D breast cancer cell proliferationin vitroas well as hormone-independent growth of MCF-7:5C cells that are resistant to long-term estrogen deprivation (80% reduction with 10 nM).2It has been shown to arrest cell cycling by downregulating cyclin D1 and ERα. 1.Komm, B.S., Kharode, Y.P., Bodine, P.V.N., et al.Bazedoxifene acetate: A selective estrogen receptor modulator with improved selectivityEndocrinology146(9)3999-4008(2005) 2.Lewis-Wambi, J.S., Kim, H., Curpan, R., et al.The selective estrogen receptor modulator bazedoxifene inhibits hormone-independent breast cancer cell growth and down-regulates estrogen receptor α and cyclin D1Mol. Pharmacol.80(4)610-620(2011) |
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