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Colchicine-d6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Colchicine-d6图片
CAS NO:1217651-73-4
包装:1mg
市场价:4763元

产品介绍
秋水仙碱-d6 是氘标记的秋水仙碱。秋水仙碱是一种微管蛋白抑制剂和微管破坏剂。秋水仙碱抑制微管聚合,IC50 为 3 nM。秋水仙碱也是 α3 甘氨酸受体 (GlyRs) 的竞争性拮抗剂。
Cas No.1217651-73-4
别名秋水仙素 d6
Canonical SMILESCOC1=C(OC)C(OC)=CC2=C1C(C([C@@H](NC(C([2H])([2H])[2H])=O)CC2)=C3)=CC=C(OC([2H])([2H])[2H])C3=O
分子式C22H19D6NO6
分子量405.5
溶解度Chloroform: Slightly Soluble,Methanol: Slightly Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Colchicine-d6is intended for use as an internal standard for the quantification of colchicine by GC- or LC-MS. Colchicine is an inhibitor of microtubule polymerization (IC50= 3.2 μM) that binds to tubulin, which disrupts spindle formation during mitosis.1It inhibits growth of MCF-7 human breast carcinoma cells with an IC50value of 13 nM.1Colchicine has anti-inflammatory activity, inhibiting neutrophil motility and activity when used at a dose of 5 μmol/kg in a mouse model of gout and preventing the deposition of uric acid.2,3

1.Martino, G.D., Regina, G.L., Coluccia, A., et al.Arylthioindoles, potent inhibitors of tubulin polymerizationJ. Med. Chem.47(25)6120-6123(2004) 2.McCarty, D.J.Urate crystals, inflammation, and colchicineArthritis Rheum.58(2)S20-S24(2008) 3.Chia, E.W., Grainger, R., and Harper, J.L.Colchicine suppresses neutrophil superoxide production in a murine model of gouty arthritis: A rationale for use of low-dose colchicineBr. J. Pharmacol.153(6)1288-1295(2008)