| CAS NO: | 79127-35-8 |
| 包装: | 1mg |
| 市场价: | 4521元 |
| Cas No. | 79127-35-8 |
| 别名 | (-)-棘孢链菌素 |
| Canonical SMILES | O[C@@]12[C@]3([H])[C@@](C=C2)([H])[C@H](OC1=O)OC(C(N)=O)=C3 |
| 分子式 | C10H9NO5 |
| 分子量 | 223.2 |
| 溶解度 | DMF: soluble,Methanol: soluble,Water: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Echinosporin is a bacterial metabolite originally isolated fromStreptomyces echinosporusthat has antibacterial and anticancer activities.1,2,3It is active againstP. vulgaris,S. typhosa,S. sonnei,E. coli, andB. subtilis(MICs = 100, 100, 100, 200, and 400 µg/ml, respectively).1Echinosporin induces cell cycle arrest at the G2/M phase and apoptosis in, as well as inhibits proliferation of, HCT-15 human colorectal cancer cells (IC50s = 1.7, 1.75, and 247 µM, respectively).2It inhibits tumor growth in murine P388 leukemia and Meth 1 fibrosarcoma models when administered at doses ranging from 10 to 80 mg/kg.3 1.Sato, T., Kawamoto, I., Oka, T., et al.A new antibiotic echinosporin (XK-213) - producing organism, isolation and characterizationJ. Antibiot. (Tokyo)35(3)266-271(1982) 2.Cui, C.B., Liu, H.B., Gu, J.Y., et al.Echinosporins as new cell cycle inhibitors and apoptosis inducers from marine-derived Streptomyces albogriseolusFitoterapia78(3)238-240(2007) 3.Morimoto, M., and Imai, R.Antitumor activity of echinosporinJ. Antibiot. (Tokyo)38(4)490-495(1985) |
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