| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Canonical SMILES | N=C(N)NCCC[C@H](NC(CN)=O)C(NCC(N[C@@H](CS(O)(=O)=O)C(N[C@@H]([C@H](O)C)C(N1[C@@H](CCC1)C(O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O |
| 分子式 | C22H39N9O11S•XCF3COOH |
| 分子量 | 637.7 |
| 溶解度 | DMSO: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Risuteganib is an anti-integrin peptide and a derivative of RGD peptide .1Risuteganib (400 µM) protects against hydroquinone-induced necrosis and apoptosis, as well as inhibits hydroquinone-induced production of reactive oxygen species (ROS), in human retinal pigment epithelial (RPE) cells.2It decreases the expression ofBAX,VEGFA, andITB1in human age-related macular degeneration (AMD) cybrid cell lines when used at a concentration of 20 mg/ml.3Risuteganib arrests aberrant blood vessel growth mediated by αVβ3, αVβ5, and α5β1 integrinsin vivo.1 1.Kaiser, P., Boyer, D.D., Campochiaro, P.A., et al.Integrin peptide therapy: The first wet AMD experienceInvest. Opth. Vis. Sci.54(15)2177(2013) 2.Yang, P., Shao, Z., Besley, N.A., et al.Risuteganib protects against hydroquinone-induced injury in human RPE cellsInvest. Ophthalmol. Vis. Sci.61(10)35(2020) 3.Differential effects of risuteganib and bevacizumab on AMD cybrid cellsExp. Eye Res.203108287(2021) |
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