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19-O-Acetylchaetoglobosin A
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
19-O-Acetylchaetoglobosin A图片
CAS NO:50939-69-0
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
19-O-Acetylchaetoglobosin A 是一种细胞松弛素生物碱，是一种真菌代谢物，最初是从 C. globosum 中分离出来的，具有肌动蛋白聚合抑制和细胞毒活性。 19-O-Acetylchaetoglobosin A 对 HeLa 宫颈癌细胞具有细胞毒性。
Cas No.50939-69-0
Canonical SMILES[H][C@]1(/C=C/C[C@H](C)/C=C2C)[C@]3([H])O[C@@]3([C@H]([C@]4([C@@H](NC([C@]41C(/C=C/C([C@@H]\2OC(C)=O)=O)=O)=O)CC5=CNC6=C5C=CC=C6)[H])C)C
分子式C34H38N2O6
分子量570.7
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

19-O-Acetylchaetoglobosin A is a fungal metabolite originally isolated fromC. globosumthat has actin polymerization inhibitory and cytotoxic activities.1,2It inhibits actin polymerization in a cell-free assay when used at a concentration of 2 µM.219-O-Acetylchaetoglobosin A (3.2, 10, and 32 µg/ml) is cytotoxic to HeLa cervical cancer cells.1

1.Umeda, M., Ohtsubo, K., Saito, M., et al.Cytotoxicity of new cytochalasans from Chaetomium globosumExperientia31(4)435-438(1975) 2.Sekita, S., Yoshihira, K., Natori, S., et al.Structure-activity relationship of thirty-nine cytochalasans observed in the effects on cellular structures and cellular events and on actin polymerization in vitroJ. Pharmacobiodyn.8(11)906-916(1985)