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Sydowinin B
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sydowinin B图片
CAS NO:58450-00-3
包装与价格:
包装价格(元)
250µg电议
1mg电议

产品介绍
A xanthone polyketide with immunosuppressant activity
Cas No.58450-00-3
Canonical SMILESO=C(C(C(O)=CC=C1OC2=CC(CO)=CC(O)=C23)=C1C3=O)OC
分子式C16H12O7
分子量316.3
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Sydowinin B is a xanthone polyketide that has been found inA. sydowiiand has immunosuppressant activity.1It inhibits LPS- or concanavalin A-induced proliferation of isolated mouse splenic lymphocytes (IC50s = 19.2 and 20.8 µg/ml, respectively).2Sydowinin B inhibits superoxide generation in, and elastase release from, isolated human neutrophils induced by cytochalasin B and N-Formyl-Met-Leu-Phe with IC50values of 21.2 and 12.62 µM, respectively.3

1.Hamasaki, T., Sato, Y., and Hatsuda, Y.Structure of sydowinin A, sydowinin B, and sydowinol, metabolites from Aspergillus sydowiAgr. Biol. Chem.39(12)2341-2345(1975) 2.Liu, H., Chen, S., Liu, W., et al.Polyketides with immunosuppressive activities from mangrove endophytic fungus Penicillium sp. ZJ-SY2Mar. Drugs14(12)217(2016) 3.Chung, Y.-M., Wei, C.-K., Chuang, D.-W., et al.An epigenetic modifier enhances the production of anti-diabetic and anti-inflammatory sesquiterpenoids from Aspergillus sydowiiBioorg. Med. Chem.21(13)3866-3872(2013)