| CAS NO: | 19428-14-9 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 100mg | 电议 |
| Cas No. | 19428-14-9 |
| 别名 | 磷酸苯丙哌林 |
| Canonical SMILES | CC(N1CCCCC1)COC2=CC=CC=C2CC3=CC=CC=C3.O=P(O)(O)O |
| 分子式 | C21H30NO5P |
| 分子量 | 407.44 |
| 溶解度 | DMSO : 250 mg/mL (613.59 mM) |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Benproperine phosphate is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate has the potential for a cough suppressant and suppresses cancer cell migration and tumor metastasis[1]. Benproperine phosphate (20-120 µM; for 24?hours) inhibits cell viability in a dose-dependent manner[1]. Benproperine phosphate (10 µM; for 24?hours) significantly inhibits the migration of various types of cancer cells and inhibits the migration and invasion of DLD-1, AsPC-1 cells with IC50 values of 1-2?µM. Benproperine phosphate (10 µM; for 24?hours) does not affect cortactin-rich lamellipodium in MCF-10A cells[1]. Benproperine phosphate (50, 100mg/kg; oral gavage; 5?days per week for 4?weeks) inhibits primary pancreatic tumor growth[1]. Benproperine phosphate shows a marked decrease in the lung metastasis of AsPC-1 cells (56.1% inhibition) in mouse. Benproperine phosphate significantly suppressed the liver metastasis of HCT-116 cells by 78.9% and DLD-1 cells by 78.2%[1]. References: |
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