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WEE1-IN-3
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
WEE1-IN-3图片
CAS NO:2272976-28-8
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
WEE1-IN-3 是一种有效的 Wee1 激酶抑制剂，其 IC50<10 nM。WEE1-IN-3 具有抗癌活性。
Cas No.2272976-28-8
分子式C28H31N7O2
分子量497.59
溶解度DMSO : 250 mg/mL (502.42 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

WEE1-IN-3 is a potent Wee1 kinase inhibitor with an IC50 of<10 nM. WEE1-IN-3 has anticancer activities[1].

WEE1-IN-3 (example 1) inhibits cancer cell growth with IC50 values of 100-1000 nM and<100 nM for SW480 cells and H23 cells, respectively[1].WEE1 kinase plays a role in the G2-M cell-cycle checkpoint arrest for ?Να repair before mitotic entry. Normal cells repair damaged DNA during GI arrest. Cancer cells often have a deficient G i-S checkpoint and depend on a functional G2-M checkpoint for DNA repair. WEE1 is overexpressed in various cancer types[1].

[1]. Peter Qinhua HUANG, et al. 1, 2 - dihydro- 3h- pyrazolo [3, 4 - d] pyrimidin -3 - one analogs. WO2019028008A1.