| CAS NO: | 2376146-48-2 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
ZN-c3 是一种口服活性、高效和选择性 Wee1 抑制剂 (IC50=3.9 nM)。ZN-c3 可用于癌症研究。
| Cas No. | 2376146-48-2 |
| 分子式 | C29H34N8O2 |
| 分子量 | 526.63 |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | ZN-c3 is an orally active, highly potent and selective Wee1 inhibitor (IC50=3.9 nM). ZN-c3 can be used for the research of cancer[1]. ZN-c3 IC50 is 103 nM in H23c cells[1]. ZN-c3 (80 mg/kg; p.o.; 28 days) can effectively shrank tumors at 80 mg/kg as a single agent[1].ZN-c3 shows excellent exposures and bioavailability in the dog PK study[1]. [1]. Huang PQ, et al. Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer [published online ahead of print, 2021 Aug 23]. J Med Chem. 2021;10.1021/acs.jmedchem.1c01121. |
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