| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Canonical SMILES | CC(C=CC=C1)=C1NC(NC(C=C2)=CC=C2CC(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N3[C@@H](CCC3)C(O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O |
| 分子式 | C36H48N6O9• XCF3COOH |
| 分子量 | 708.8 |
| 溶解度 | DMSO: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | BIO-1211 is a peptide inhibitor of α4β1 integrin (IC50= 0.004 µM).1It is selective for α4β1 integrin over α4β7 (IC50= 2 µM), as well as α1β1, α5β1, α6β1, αLβ2, and αIIbβ3 (IC50s = >100 µM for all). BIO-1211 binds to α4β1 (IC50= 1 nM) and inhibits Jurkat cell adhesion (IC50= 4 nM). Inhaled administration of BIO-1211 (3 mg/animal) prevents carbachol-induced airway hyperresponsiveness in an ovine model of allergy-induced asthma. 1.Lin, K.c., Ateeq, H.S., Hsiung, S.H., et al.Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responsesJ. Med. Chem.42(5)920-934(1999) |
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