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(+)-JNJ-A07
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(+)-JNJ-A07图片
CAS NO:2135640-93-4
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
(+)-JNJ-A07 是一种靶向 NS3-NS4B 相互作用的高效泛血清型登革热病毒抑制剂。(+)-JNJ-A07 对 21 株临床分离株发挥纳摩尔到皮摩尔的活性。(+)-JNJ-A07 具有良好的药代动力学特征，在小鼠感染模型中对登革热病毒感染有显著疗效。
Cas No.2135640-93-4
分子式C28H26ClF3N2O6
分子量578.96
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(+)-JNJ-A07 is a highly potent, orally active pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction. (+)-JNJ-A07 exerts nanomolar to picomolar activity against a panel of 21 clinical isolates. (+)-JNJ-A07 has a favourable pharmacokinetic profile that results in outstanding efficacy against dengue virus infection in mouse infection models[1].

(+)-JNJ-A07 has a high barrier to resistance and prevents the formation of the viral replication complex by blocking the interaction between two viral proteins (NS3 and NS4B)[1].

[1]. Kaptein SJF, et al. A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction [published correction appears in Nature. 2021 Nov;599(7883):E2]. Nature. 2021;598(7881):504-509.