HIV-1 inhibitor-6

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HIV-1 inhibitor-6

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议

产品介绍

HIV-1 inhibitor-6 (compound 9) 是一种基于二杂芳基酰胺的化合物，是一种有效的 HIV-1 pre-mRNA 选择性剪接抑制剂。HIV-1 inhibitor-6 可以阻断 HIV 复制。HIV-1 inhibitor-6 对野生型 HIV-1IIIB (亚型 B，X4-tropic) 和 HIV-1 97USSN54 (亚型 A，R5-tropic) 具有活性，EC50 值分别为 0.6 μM 和 0.9 μM。HIV-1 inhibitor-6 抑制对靶向 HIV 逆转录酶、蛋白酶、整合酶和辅助受体 CCR5 的药物耐药的 HIV 菌株，EC50 范围为 0.9 至 1.5 μM。

X4HIV-1(III_B)

0.6μM(EC₅₀)

R5HIV-1

0.9μM(EC₅₀)

产品描述

HIV-1 inhibitor-6 (compound 9), a diheteroarylamide-based compound, is a potent HIV-1 pre-mRNA alternative splicing inhibitor. HIV-1 inhibitor-6 blocks HIV replication. HIV-1 inhibitor-6 is active against wild-type HIV-1IIIB (subtype B, X4-tropic) and HIV-1 97USSN54 (subtype A, R5-tropic) with EC50s of 0.6 μM and 0.9 μM, respectively. HIV-1 inhibitor-6 inhibits HIV strains resistant to drugs targeting HIV reverse transcriptase, protease, integrase, and coreceptor CCR5 with EC50s ranging from 0.9 to 1.5 μM[1].

[1]. Peter K Cheung, et al. A Parallel Synthesis Approach to the Identification of Novel Diheteroarylamide-Based Compounds Blocking HIV Replication: Potential Inhibitors of HIV-1 Pre-mRNA Alternative Splicing. J Med Chem. 2016 Mar 10;59(5):1869-79.