GSK3 Inhibitor XIII 是一种有效的 ATP 竞争性 GSK-3 抑制剂，Ki 为 24 nM。
| Cas No. | 404828-08-6 |
| Canonical SMILES | CC1=CC(NC2=NC(C3=CC=CC=C3)=NC4=C2CCCC4)=NN1 |
| 分子式 | C18H19N5 |
| 分子量 | 305.4 |
| 溶解度 | DMF: 0.25 mg/ml,DMSO: 0.15 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | GSK3 Inhibitor XIII is an aminopyrazole ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK3), with 34% inhibition when used at a concentration of 2.5 µM. It inhibits androgen receptor transactivation in 22Rv1, LNCaP, and LNCaP-SSR cell lines in a dose-dependent manner. It promotes nuclear export of the androgen receptor and decreases translocation to the nucleus in PC3 and PCa prostate cancer cells, respectively. In HEK293 cells expressing the rat Nav1.2 channel, pretreatment with GSK3 inhibitor XIII dose-dependently potentiates peak current densities. |
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