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PIK-108
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PIK-108图片
CAS NO:901398-68-3
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
PIK-108 是一种非 ATP 竞争性的,变构的 p110β/p110δ 选择性抑制剂。
Cas No.901398-68-3
别名6-甲基-2-(4-吗啉基)-8-[1-(苯基氨基)乙基]-4H-1-苯并吡喃-4-酮
分子式C22H24N2O3
分子量364.44
溶解度DMSO : 50 mg/mL (137.20 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PIK-108 is a non-ATP competitive, allosteric p110β/p110δ selective inhibitor[1].

PIK-108 (0.1-10 μM; 1 hour) blocks phosphorylation of PKB/Akt[1].

[1]. Zachary A Knight, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47.
[2]. Jack S Chen, et al. Characterization of structurally distinct, isoform-selective phosphoinositide 3’-kinase inhibitors in combination with radiation in the treatment of glioblastoma. Mol Cancer Ther. 2008 Apr;7(4):841-50.