hSMG-1 inhibitor 11e

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CAS NO:

1402452-10-1

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	电议
5mg	电议
10mg	电议

产品介绍

hSMG-1 inhibitor 11e 是一种有效的选择性的 hSMG-1 激酶抑制剂，其 IC50 值<0.05 nM。hSMG-1 inhibitor 11e 对 hSMG-1 的选择性比 mTOR (IC50 为 45 nM)，PI3Kα/γ (IC50 为 61 nM 和 92 nM) 和 CDK1/CDK2 (IC50 为 32 μM 和 7.1 μM) 高 900 倍。

Cas No.	1402452-10-1
分子式	C₂₆H₂₇N₇O₃S
分子量	517.6
溶解度	DMSO : 50 mg/mL (96.60 mM; Need ultrasonic)
储存条件	4°C, away from moisture and light
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	hSMG-1 inhibitor 11e is a potent and selective hSMG-1 kinase inhibitor with an IC50 of 900-fold selectivity over mTOR (IC50 of 45 nM), PI3Kα/γ (IC50s of 61 nM and 92 nM) and CDK1/CDK2 (IC50s of 32 μM and 7.1 μM)[1]. hSMG-1 kinase plays a dual role in a highly conserved RNA surveillance pathway termed nonsense-mediated RNA decay (NMD) and in cellular genotoxic stress response. Since deregulation of cellular responses to stress contributes to tumor growth and resistance to chemotherapy, hSMG-1 is a potential target for cancer treatment[1]. [1]. Ariamala Gopalsamy, et al. Identification of pyrimidine derivatives as hSMG-1 inhibitors. Bioorg Med Chem Lett. 2012 Nov 1;22(21):6636-41.