| CAS NO: | 73346-79-9 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 73346-79-9 |
| 别名 | 假单胞菌酸锂 |
| Canonical SMILES | C[C@H](O)[C@H](C)[C@@](O1)([H])[C@@H]1C[C@@H]2[C@H]([C@H]([C@@H](OC2)C/C(C)=C/C(OCCCCCCCCC([O-])=O)=O)O)O.[Li+] |
| 分子式 | C26H43O9·Li |
| 分子量 | 506.6 |
| 溶解度 | Ethanol: 30 mg/ml,PBS (pH 7.2): 1 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Pseudomonic acid is an antibiotic and bacterial metabolite that has been found inP. fluorescens.1It is bacteriostatic againstS. aureus(MIC = 0.05 µg/ml) and active against skin wound clinical isolates of methicillin-resistantS. aureus(MRSA; MICs = 1-4 µg/ml).2,3Pseudomonic acid inhibits MRSA andP. aeruginosabiofilm formationin vitro.4It inhibits bacterial cell wall isoleucyl-tRNA synthetase, slowing bacterial growth.2,4Topical administration of pseudomonic acid (2% v/v) reduces the number of wound colony forming units (CFUs) in a mouse model of MRSA skin infection.3 1.Fuller, A.T., Mellows, G., Woolford, M., et al.Psuedomonic acid: An antibiotic produced by Pseudomonas fluorescensNature234(5329)416-417(1971) 2.Hughes, J., and Mellows, G.On the mode of action of pseudomonic acid: Inhibition of protein synthesis in Staphylococcus aureusJ. Antibiot. (Tokyo)31(4)330-335(1978) 3.Mohammad, H., Cushman, M., and Seleem, M.N.Antibacterial evaluation of synthetic thiazole compounds in vitro and in vivo in a methicillin-resistant Staphylococcus aureus (MRSA) skin infection mouse modelPLoS One10(11)e0142321(2015) 4.Khoshnood, S., Heidary, M., Asadi, A., et al.A review on mechanism of action, resistance, synergism, and clinical implications of mupirocin against Staphylococcus aureusBiomed. Pharmacother.1091809-1818(2019) |
m.cnreagent.com