Suprastat is a novel, potent and selective HDAC6 (Histone Deacetylase 6) inhibitor with the ability to potentiate immunotherapy in melanoma. In vitro characterization of Suprastat demonstrates subnanomolar HDAC6 inhibitory potency and a hundred- to a thousand-fold HDAC6 selectivity over the other HDAC isoforms. In vivo studies reveal that a combination of Suprastat and anti-PD1 immunotherapy enhances anti-tumor immune response, mediated by a decrease of pro-tumoral M2 macrophages and increased infiltration of anti-tumor CD8+ effector and memory T-cells.

纯度：≥98%

CAS：90093-40-6